Methotrexate

CAS: 59-05-2            Structure:                        Specifications: Conforms to standard USP 27 and EP4,BP2002 Text USP27 EP4 BP2002 Assay% 98.0-102.0 98.0-102.0 98.0-102.0 Residue on ignition% ≤0.1     Specific roataion +19-+24 +19-+24   Loss on drying%       Chromatographic purity% ≤2.0(total)       ≤0.5(individual)     Water% ≤12.0 ≤13.0 ≤12.0 Organic Volatile impurites conforms Sulphated ash%   ≤0.1 ≤0.1 Heavy metals ppm   50 1 Related substance       Total   ≤1.3 ≤1.3% Individual   At most five peaks At most five peaks Impurity A%   ≤0.5 ≤0.5 Impurity B%   ≤0.5 ≤0.5 Impurity C%   ≤0.5 ≤0.5 Impurity D%   ≤0.5 ≤0.5 Impurity E%   ≤0.5 ≤0.5 Unknown Impurity %   ≤0.5 ≤0.5 (R)-Methotrexate%   ≤3.0 ≤3.0  Physical properties: Appearance: orange yellow crystal powders Solubility: the production hardly dissolves in water, ethanol, chloroform or ether, and it easily dissolves in sparse alkali, and it can dissolve in dilute hydrochloric acid.  USE: The product is used as anti-tumour medicament.  Package: It's packed 2-ply polyethylene bags are heat sealed, Net weight 1KG/Tin.